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TUM 9 BSE Genomics B
TUM 9 BSE Genomics B We aimed to investigate several candidate genes for an association with BSE susceptibility. All together, ten genes were analyzed, which were either located in putative…
LMU 22 Generation of PrPC deficient cattle
LMU 22 Generation of PrPC deficient cattle This project aimed at the generation of cattle lacking PrPC expression. Targeted inactivation of the PRNP gene was achieved in primary fetal fibroblasts…
LMU 15 BSE Genomics A
LMU 15 BSE Genomics A As an condition to make association studies between specific bovine PRNP DNA variants and a genetic disposition for BSE in cattle we genotyped 989 animals each for six PRNP-DNA…
Erl 2 BSE Genomics C
Erl 2 BSE Genomics C The aim of the study was the identification of DNA polymorphisms in the bovine prion protein gene. These polymorphisms were analyzed in control and BSE animals to identify…
LMU 21 Investigation of Sporadically Occurring Spongiform Brain Lesions in Cattle
LMU 21 Investigation of Sporadically Occurring Spongiform Brain Lesions in Cattle We performed autopsies of cattle in Bavaria with clinical suspect for BSE (bovine spongiform encephalopathy) and…
LMU 19 a Occurrence and Stability of the BSE Agent in Foodstuff (primarily in Milk and Milk Products) and in the Environment
LMU 19 a Occurrence and Stability of the BSE Agent in Foodstuff (primarily in Milk and Milk Products) and in the Environment A scientific-based risk assessment on the occurrence of the BSE agent in…
LMU 19 Clinical and Epidemiological Investigations of BSE in Bavaria
LMU 19 Clinical and Epidemiological Investigations of BSE in Bavaria A total of 1007 cattle were examined clinically, with special regard to the central nervous system. They consisted of 949 cattle…
LMU 13 Studies the genetic diversity of the porcine prion protein
LMU 13 Studies the genetic diversity of the porcine prion protein The question of the role of pigs in the transmission of the BSE agent to man will be addressed. Although intracerebral inoculation…
Bay 1 Occurence of TSE in natural habitats: Transmission of prions through wild animals and farmed wild ruminants in Northern Bavaria
Bay 1 Occurence of TSE in natural habitats: Transmission of prions through wild animals and farmed wild ruminants in Northern Bavaria During the reporting period we established a network to obtain a…
TUM 16 Development of specific recombinant anti- PrPSc antibodies
TUM 16 Development of specific recombinant anti- PrPSc antibodies The principal goal of this project was the generation of recombinant antibodies that discriminate between the cellular prion protein…