FOR-COVID

Comparison of four commercial, automated antigen tests to detect SARS‑CoV‑2 variants of concern

Andreas Osterman, Maximilian Iglhaut, Andreas Lehner,  Patricia Spaeth, Marcel Stern,
Hanna Autenrieth, Maximilian Muenchhoff,  Alexander Graf,  Stefan Krebs,  Helmut Blum, 
Armin Baiker, Natascha Grzimek-Koschewa, Ulrike Protzer,  Lars Kaderali, Hanna-Mari Baldauf, Oliver T. Keppler

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Med Microbiol Immunol. 2021 Dec;210(5-6):263-275.

doi: 10.1007/s00430-021-00719-0.

PMID: 34415422

https://link.springer.com/article/10.1007/s00430-021-00719-0

Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection

Elham Khatamzas, Markus H. Antwerpen, Alexandra Rehn, Alexander Graf, Johannes Christian Hellmuth, Alexandra Hollaus, Anne-Wiebe Mohr, Erik Gaitzsch, Tobias Weiglein, Enrico Georgi, Clemens Scherer, Stephanie-Susanne Stecher, Stefanie Gruetzner, Helmut Blum, Stefan Krebs, Anna Reischer, Alexandra Leutbecher, Marion Subklewe, Andrea Dick, Sabine Zange, Philipp Girl, Katharina Müller, Oliver Weigert, Karl-Peter Hopfner, Hans-Joachim Stemmler, Michael von Bergwelt-Baildon, Oliver T. Keppler, Roman Wölfel, Maximilian Muenchhoff, and Andreas Moosmann

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Nat Commununcations 2022 Sep 23;13(1):5586. PMID: 36151076

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508331/

Secondary zoonotic dog-to-human transmission of SARS-CoV-2 suggested by timeline but refuted by viral genome sequencing

John M. Hoppe, Louise U. Füeßl, Katrin Hartmann, Regina Hofmann‑Lehmann, Alexander Graf, Stefan Krebs, Helmut Blum, Irina Badell, Oliver T. Keppler, Maximilian Muenchhoff

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Infection. 2023 51:253–259. PMID: 35986880

https://link.springer.com/article/10.1007/s15010-022-01902-y

Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests

Andreas Osterman, Irina Badell, Christopher Dächert, Nikolas Schneider, Anna‑Yasemin Kaufmann, Gamze Naz Öztan, Melanie Huber, Patricia M. Späth, Marcel Stern,  Hanna Autenrieth, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Ludwig Czibere, Jürgen Durner, Lars Kaderali, Hanna‑Mari Baldauf, Oliver T. Keppler

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Medical Microbiology and Immunology. 2023 212:13–23. PMID: 36370197

https://link.springer.com/article/10.1007/s00430-022-00752-7

Impaired detection of omicron by SARS-CoV-2 rapid antigen tests

Andreas Osterman, Irina Badell, Elif Basara, Marcel Stern, Fabian Kriesel, Marwa Eletreby, Gamze Naz Öztan, Melanie Huber, Hanna Autenrieth, Ricarda Knabe, Patricia M. Späth, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Jürgen Durner, Ludwig Czibere, Christopher Dächert, Lars Kaderali, Hanna‑Mari Baldauf, Oliver T. Keppler

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Med Microbiol Immunol. 2022 Jun;211(2-3):105-117. PMID: 35187580

https://link.springer.com/article/10.1007/s00430-022-00730-z

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.

Paul R. Wratil, Marcel Stern, Alina Priller, Annika Willmann, Giovanni Almanzar, Emanuel Vogel, Martin Feuerherd, Cho-Chin Cheng, Sarah Yazici, Catharina Christa, Samuel Jeske, Gaia Lupoli, Tim Vogt, Manuel Albanese, Ernesto Mejias-Perez, Stefan Bauernfried, Natalia Graf, Hrvoje Mijocevic, Martin Vu, Kathrin Tinnefeld, Jochen Wettengel, Dieter Hoffmann, Maximilian Münchhoff, Christopher Daechert, Helga Mairhofer, Stefan Krebs, Volker Fingerle, Alexander Graf, Philipp Steininger, Helmut Blum, Veit Hornung, Bernhard Liebl, Klaus Überla, Martina Prelog, Percy Knolle, Oliver T. Keppler & Ulrike Protzer

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Nature Medicine 2022, 28:496-503. PMID: 35090165

https://www.nature.com/articles/s41591-022-01715-4

Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants

Christopher Dächert, Maximilian Muenchhoff, Alexander Graf, Hanna Autenrieth, Sabine Bender, Helga Mairhofer, Paul R. Wratil, Susanne Thieme, Stefan Krebs, Natascha Grzimek‑Koschewa, Helmut Blum, Oliver T. Keppler

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Med Microbiol Immunol. 2022 Feb;211(1):71-77. PMID: 35061086

https://link.springer.com/article/10.1007/s00430-022-00728-7

Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma

Andrea Keppler-Hafkemeyer, Christine Greil, Paul R. Wratil, Khalid Shoumariyeh, Marcel Stern, Annika Hafkemeyer, Driti Ashok, Alexandra Hollaus, Gaia Lupoli, Alina Priller, Marie L. Bischof, Gabriele Ihorst, Monika Engelhardt, Reinhard Marks, Jürgen Finke, Hannah Bertrand, Christopher Dächert, Maximilian Muenchhoff, Irina Badell, Florian Emmerich, Hridi Halder, Patricia M. Spaeth, Percy A. Knolle, Ulrike Protzer, Michael von Bergwelt-Baildon, Justus Duyster, Tanja N. Hartmann, Andreas Moosmann and Oliver T. Keppler

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Nature Cancer 2022, 4(1): 85-91. PMID: 36543907

https://doi.org/10.1038/s43018-022-00502-x

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger, Niklas Kuhl, Andreas Linder, Kathrin Saar, Lukas Tomas, Christian Schulz, Andreas Wieser, Wolfgang Enard, Inge Kroidl, Christof Geldmacher, Michael von Bergwelt-Baildon, Oliver T. Keppler, Mathias Munschauer, Matteo Iannacone, Ralf Zimmer, Philipp Mertins, Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, and Leo Nicolai

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Nature Communications 2022 Feb 23;13(1):1018. PMID: 35197461

https://doi.org/10.1038/s41467-022-28508-0

Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.

Nina Koerber, Alina Priller, Sarah Yazici, Tanja Bauer, Cho-Chin Cheng, Hrvoje Mijočević, Hannah Wintersteller, Samuel Jeske, Emanuel Vogel, Martin Feuerherd, Kathrin Tinnefeld, Christof Winter, Jürgen Ruland, Markus Gerhard, Bernhard Haller, Catharina Christa, Otto Zelger, Hedwig Roggendorf, Martin Halle, Johanna Erber, Paul Lingor, Oliver Keppler, Dietmar Zehn, Ulrike Protzer & Percy A. Knolle

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Nature Communications 2022, 13(1):153. PMID: 35013191

https://www.nature.com/articles/s41467-021-27649-y

Long-term monitoring of SARS-CoV-2 seroprevalence and variants in Ethiopia provides prediction for immunity and cross-immunity

Simon Merkt, Solomon Ali, Esayas Kebede Gudina, Wondimagegn Adissu, Addisu Gize, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Kira Elsbernd, Rebecca Kisch, Sisay Sirgu Betizazu, Bereket Fantahun, Delayehu Bekele, Raquel Rubio-Acero, Mulatu Gashaw, Eyob Girma, Daniel Yilma, Ahmed Zeynudin, Ivana Paunovic, Michael Hoelscher, Helmut Blum, JanHasenauer, Arne Kroidl, Andreas Wieser

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Nature Comm 2024 15:3463. PMID: 38658564

https://doi.org/10.1038/s41467-024-47556-2

Viral genome sequencing to decipher in‑hospital SARS‑CoV‑2 transmission events

Elisabeth Esser, Eva C. Schulte, Alexander Graf, Alexander Karollus, Nicholas H. Smith, Thomas Michler, Stefan Dvoretskii, Angel Angelov, Michael Sonnabend, Silke Peter, Christina Engesser, Aleksandar Radonic, Andrea Thürmer, Max von Kleist, Friedemann Gebhardt, Clarissa Prazeres da Costa, Dirk H. Busch, Maximilian Muenchhoff, Helmut Blum, Oliver T. Keppler, Julien Gagneur, Ulrike Protzer

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Sci Rep 2024 14:5768. PMID: 39459123

https://doi.org/10.1038/s41598-024-56162-7

Impaired immune responses and prolonged viral replication in lung allograft recipients infected with SARS‑CoV‑2 in the early phase after transplantation

Olaf M. Glueck, Xiaoling Liang, Irina Badell, Paul R. Wratil, Alexander Graf, Stefan Krebs, Helmut Blum, Johannes C. Hellmuth, Clemens Scherer, Alexandra Hollaus, Patricia M. Spaeth, Burak Karakoc, Thimo Fuchs, Julia Zimmermann, Teresa Kauke, Andreas Moosmann,  Oliver T. Keppler, Christian Schneider, Maximilian Muenchhoff

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Infection 2023 Nov 3. doi: 10.1007/s15010-023-02116-6. Online ahead of print

PMID: 37922037

https://doi.org/10.1007/s15010-023-02116-6

Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages

Andreas Osterman, Franziska Krenn, Maximilian Iglhaut, Irina Badell, Andreas Lehner, Patricia M. Späth, Marcel Stern, Hanna Both, Sabine Bender, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Timo Grimmer, Jürgen Durner, Ludwig Czibere, Christopher Dächert, Natascha Grzimek‑Koschewa, Ulrike Protzer, Lars Kaderali, Hanna‑Mari Baldauf, Oliver T. Keppler

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Med Microbiol Immunol 2023 212(5):307-322. PMID: 37561226.

https://doi.org/10.1007/s00430-023-00774-9

Longitudinal SARS-CoV-2 neutralization of Omicron BA. 1, BA. 5 and BQ. 1.1 after four vaccinations and the impact of break-through infections in hemodialysis patients

Louise Platen, Bo-Hung Liao, Myriam Tellenbach, Cho-Chin Cheng, Christopher Holzmann-Littig, Catharina Christa, Christopher Dächert, Verena Kappler, Romina Bester, Maia Lucia Werz, Emely Schönhals, Eva Platen, Peter Eggerer, Laëtitia Tréguer , Claudius Küchle, Christoph Schmaderer, Uwe Heemann, Oliver T. Keppler, Lutz Renders, Matthias Christoph Braunisch, and Ulrike Protzer

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Clin Kidney J. 2023, 16(12):2447-2460. PMID: 38046025;

DOI: 10.1093/ckj/sfad147