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Wü 1 Pathogenesis of Prion Diseases IV
Wü 1 Pathogenesis of Prion Diseases IV Oxidative stress in the brain at early preclinical stages of mouse scrapie Oxidative stress has been shown to be involved in the pathogenesis of…
Wü 1 Pathogenesis of Prion Diseases III
Wü 1 Pathogenesis of Prion Diseases III The effect of mouse prions on primary neurons was studied on cultured motoneurons of embryonic mice. We found that cells developed a mouse prion-specific…
Wü 1 Pathogenesis of Prion Diseases II
Wü 1 Pathogenesis of Prion Diseases II The spread of prions in mouse scrapie involves cells of the peripheral nervous system and cells of the immune system. It is not yet known, whether immune cells…
Wü 1 Pathogenesis of Prion Diseases I
Wü 1 Pathogenesis of Prion Diseases I Peripheral exposure is the most common route for transmission of prion diseases. To understand the spread of peripherally administered prions to the brain, we…
TUM 7 The Role of Activated Retroviral Genes as Cofactors in Prion-induced Spongiform Encephalopathy: Studies with a Mouse Model for Pathogenesis and Therapy
TUM 7 The Role of Activated Retroviral Genes as Cofactors in Prion-induced Spongiform Encephalopathy: Studies with a Mouse Model for Pathogenesis and Therapy Prions as causative agents of…
LMU 11 Function of Dendritic Cells (DC) in the Pathogenesis of Prion Disease
LMU 11 Function of Dendritic Cells (DC) in the Pathogenesis of Prion Disease The path of infection of prion proteins within the mammal's organism is almost unknown. Especially it is not clear how…
TUM 9 BSE Genomics B
TUM 9 BSE Genomics B We aimed to investigate several candidate genes for an association with BSE susceptibility. All together, ten genes were analyzed, which were either located in putative…
LMU 22 Generation of PrPC deficient cattle
LMU 22 Generation of PrPC deficient cattle This project aimed at the generation of cattle lacking PrPC expression. Targeted inactivation of the PRNP gene was achieved in primary fetal fibroblasts…
LMU 15 BSE Genomics A
LMU 15 BSE Genomics A As an condition to make association studies between specific bovine PRNP DNA variants and a genetic disposition for BSE in cattle we genotyped 989 animals each for six PRNP-DNA…
Erl 2 BSE Genomics C
Erl 2 BSE Genomics C The aim of the study was the identification of DNA polymorphisms in the bovine prion protein gene. These polymorphisms were analyzed in control and BSE animals to identify…